Vascular graft infection: Detection by 123I-labeled antigranulocyte antibody (anti-NCA95) scintigraphy

M. Cordes, W. Hepp, R. Langer, J. Pannhorst, J. Hierholzer, R. Felix

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

A total of 40 scintigraphic examinations were performed after vascular reconstructive surgery in 27 patients in whom there was a clinical suspicion of vascular graft infection. Whole-body gamma camera images were obtained at 4 and 24 h after i. v. administration of 111 MBq 123I-labeled antigranulocyte antibody Anti-NCA95. Scan results were interpreted without clinical information and were subsequently correlated with computed tomography. Prosthetic vascular graft infection was confirmed in 9 patients and excluded in 18 by surgical findings, bacteriology and/or clinical course. Scintigraphy revealed true-positive results in 18 of 40 and false-negative results in 1 of 40 examinations. True-negative results were found in 10 and 16, false-positive results in 4 and 7 examinations at 4 and 24 h p.i., resp. The sensitivity was calculated to be 94% for both early (4h) and late (24 h) images whereas the specificity was 83% and 70%, resp. In all cases the application of the murine antibody was safe and no side effects or complications were noted. Limitations of this diagnostic procedure are accumulations of granulocytes in hematomas which may be observed in the non-complicated early course following reconstructive surgery.

Original languageEnglish
Pages (from-to)173-177
Number of pages5
JournalNuklearMedizin
Volume30
Issue number5
DOIs
Publication statusPublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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