Transmission of Mycobacterium tuberculosis depending on the age and sex of source cases

Martien W. Borgdorff, Nico J.D. Nagelkerke, Petra E.W. De Haas, Dick Van Soolingen

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)

Abstract

This study estimated to what extent tuberculosis transmission in the Netherlands depends on the age and sex of source cases. DNA fingerprints of Mycobacterium tuberculosis isolates were matched to patient information in the Netherlands Tuberculosis Register for 1993-1998. Clusters were defined as groups of patients with pulmonary tuberculosis whose isolates had identical DNA fingerprints. Source cases were assigned by using two models. The first-case model assumed that the first diagnosed case was the source case. The incidence rate model estimated source case probabilities from the incidence rates of potential source cases and the time of diagnosis. DNA fingerprints of 6,102 isolates were matched to patient information on 5,080 (83%) cases, 3,479 of whom had pulmonary disease. According to both models, the number of infectious cases generated per source case was lower for female than for male source cases and decreased with increasing age of the source case. The authors concluded that transmission of tuberculosis is associated with the age and sex of source cases as well as the age of secondary cases. Increased transmission among immigrant groups in the Netherlands is largely attributable to the relatively young age of immigrant source cases.

Original languageEnglish
Pages (from-to)934-943
Number of pages10
JournalAmerican Journal of Epidemiology
Volume154
Issue number10
DOIs
Publication statusPublished - Nov 15 2001

Keywords

  • Age distribution
  • Polymorphism
  • Pulmonary
  • Restriction fragment length
  • Sex
  • Tuberculosis

ASJC Scopus subject areas

  • Epidemiology

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