Toxicity assessment of date pit activated carbon nanomaterials in hepatocytes

Betty Titus Mathew, Shaima Raji, A. H.I. Mourad, Ali Hilal-Alnaqbi, Khaled A. El-Tarabily, Amr Amin, Fadi Alnaimat, Bobby Mathew

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

This main objective of this work is to synthesize and characterize activated carbon (AC) produced from date pits and screening of cytotoxicity assay with carbon nanoparticles on hepatocytes namely (THLE2 and Hep G2). The AC was prepared by physical activation method at 900C in a tube furnace. Scanning Electron Microscopy analysis illustrated that the activation has increased the pores intensity. In the biological assays, cytotoxicity test of the THLE2 cells and HepG2 cells showed viability remained closed to 100% when exposed to date pit carbon nanomaterial. Transmission Electron Microscopy (TEM) was conducted to check the apoptosis severity of nanoparticles on the cells. The results showed that the cells regained its capacity even when the particles were ingested by the cells.

Original languageEnglish
Title of host publication2019 Advances in Science and Engineering Technology International Conferences, ASET 2019
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538682715
DOIs
Publication statusPublished - May 14 2019
Event2019 Advances in Science and Engineering Technology International Conferences, ASET 2019 - Dubai, United Arab Emirates
Duration: Mar 26 2019Apr 10 2019

Publication series

Name2019 Advances in Science and Engineering Technology International Conferences, ASET 2019

Conference

Conference2019 Advances in Science and Engineering Technology International Conferences, ASET 2019
Country/TerritoryUnited Arab Emirates
CityDubai
Period3/26/194/10/19

Keywords

  • Cytotoxicity
  • DLS
  • Date pit Activated carbon
  • Hepatocytes
  • TEM
  • Zeta-potential

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Artificial Intelligence
  • Computer Networks and Communications
  • Energy Engineering and Power Technology
  • Civil and Structural Engineering
  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Ceramics and Composites

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