The use of BrCCl3-PPh3 in Appel type transformations to esters, O-acyloximes, amides, and acid anhydrides

Mariam Al-Azani, Mazen al-Sulaibi, Nuha al Soom, Yosef Al Jasem, Bernhard Bugenhagen, Bassam Al Hindawi, Thies Thiemann

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Esters, acyloximes, amides and acid anhydrides have been prepared from the respective carboxylic acids, oximes, amines and alcohols by the use of the reagent combination BrCCl3-PPh3. The reactions obviate the handling acyl halides or more aggressive reagents PCl3, POCl3, or SOCl2. Furthermore, the environmentally hazardous CCl4 used in Appel-type reactions is replaced with BrCCl3, a reagent of less environmental concern.

Original languageEnglish
Pages (from-to)921-932
Number of pages12
JournalComptes Rendus Chimie
Volume19
Issue number8
DOIs
Publication statusPublished - Aug 1 2016

Keywords

  • Acid anhydrides
  • Amidation
  • Appel reaction
  • Bromotrichlorocarbon
  • Esterification
  • O-acyloximes

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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