The stomach is a source of leptin

André Bado, Sandrine Levasseur, Samir Attoub, Stéphanie Kermorgant, Jean Pierre Laigneau, Marie Noëlle Bortoluzzi, Laurent Moizo, Thérèse Lehy, Michèle Guerre-Millo, Yannick Le Marchand-Brustel, Miguel J.M. Lewin

Research output: Contribution to journalArticlepeer-review

1027 Citations (Scopus)

Abstract

The circulating peptide leptin, which is the product of the ob gene, provides feedback information on the size of fat stores to central Ob receptors that control food intake and body-weight homeostasis. Leptin has so far been reported to be secreted only by adipocytes and the placenta. Here we show that leptin messenger RNA and leptin protein are present in rat gastric epithelium, and that cells in the glands of the gastric fundic mucosa are immunoreactive for leptin. The physiological function of this previously unsuspected source of leptin is unknown. However, both feeding and administration of CCK-8 (the biologically active carboxy-terminal end of cholecystokinin) result in a rapid and large decrease in both leptin cell immunoreactivity and the leptin content of the fundic epithelium, with a concomitant increase in the concentration of leptin in the plasma. These results indicate that gastric leptin may be involved in early CCK-mediated, effects activated by food intake, possibly including satiety.

Original languageEnglish
Pages (from-to)790-793
Number of pages4
JournalNature
Volume394
Issue number6695
DOIs
Publication statusPublished - Aug 20 1998
Externally publishedYes

ASJC Scopus subject areas

  • General

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