The primary structure of ratfish insulin reveals an unusual mode of proinsulin processing

J. Michael Conlon, Eva Dafgård, Sture Falkmer, Lars Thim

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The primary structure of insulin from the Holocephalan fish, Hydrolagus colliei (the ratfish), has been established by automated Edman degradation as: {A figure is presented}.

Original languageEnglish
Pages (from-to)445-450
Number of pages6
JournalFEBS Letters
Volume208
Issue number2
DOIs
Publication statusPublished - Nov 24 1986
Externally publishedYes

Keywords

  • (Ratfish pancreas) Holocephalan Insulin C-peptide HPLC
  • The presence of a COOH-terminal extension to the B-chain is consistent with the occurrence of a single base mutation in the region of the gene encoding one of the dibasic residue processing sites

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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