The peptidyl-prolyl isomerase pin1 up-regulation and proapoptotic function in dopaminergic neurons: Relevance to the pathogenesis of parkinson disease

Anamitra Ghosh, Hariharan Saminathan, Arthi Kanthasamy, Vellareddy Anantharam, Huajun Jin, Gautam Sondarva, Dilshan S. Harischandra, Ziqing Qian, Ajay Rana, Anumantha G. Kanthasamy

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)

Abstract

Background: Pin1 regulates several signaling proteins by isomerizing the cis/trans conformation of the Ser(P)-Pro peptide bond. Results: Pin1 is up-regulated in dopaminergic neurons in cell culture, animal models, and human PD brains. Pin1 inhibition protects dopaminergic neurons in PD models. Conclusion: Pin1 up-regulation plays a proapoptotic function in PD. Significance: Pin1 inhibition may be a viable translational strategy in PD.

Original languageEnglish
Pages (from-to)21955-21971
Number of pages17
JournalJournal of Biological Chemistry
Volume288
Issue number30
DOIs
Publication statusPublished - Jul 26 2013
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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