The importance of core groups in the epidemiology and control of HIV-1 infection

F. A. Plummer, N. J.D. Nagelkerke, S. Moses, J. O. Ndinya-Achola, J. Bwayo, E. Ngugi

Research output: Contribution to journalReview articlepeer-review

122 Citations (Scopus)

Abstract

In Africa, HIV transmission occurs mainly through heterosexual intercourse. High-frequency transmitter core groups are key to the epidemiology of HIV-1 and STD on the continent. The rapid growth of the HIV-1 epidemic in Africa appears to have resulted, in part, from social and economic factors which result in individuals' frequent engagement in sexual intercourse with members of HIV-infected core groups. Understanding the importance of core groups in HIV-1 transmission is therefore key to developing more effective programs for the control of HIV-1. Sections explore the core groups concept and the sexual transmission of infection, social and economic forces creating core groups in Africa, the interaction of STD and HIV-1 in core groups, the effect of STD on HIV-1 disease progression in core groups in accelerating the HIV-1 epidemic, the role of core group interventions in control programs, balancing disease control with the potential for victimization, and research needs.

Original languageEnglish
Pages (from-to)S169-S176
JournalAIDS
Volume5
Issue numberSUPPL. 1
Publication statusPublished - Dec 1 1991

Keywords

  • Core groups
  • HIV-1
  • Long-distance truck drivers
  • Prostitutes
  • Sexually transmitted diseases
  • Transmission

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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