The importance of cholinergic tone in the release of pancreatic polypeptide by gut hormones in man

T. E. Adrian, H. S. Besterman, S. R. Bloom

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

The pancreatic polypeptide response to both caerulein and Boots' secretin was greatly obtuned by prior administration of atropine. In addition basal plasma PP concentration fell by 54 ± 7% (mean ± SEM p < 0.001) 30 minutes after atropinisation. Some degree of cholinergic tone thus appears essential both for maintaining basal PP levels and for the response to gut hormones.

Original languageEnglish
Pages (from-to)1989-1993
Number of pages5
JournalLife Sciences
Volume24
Issue number21
DOIs
Publication statusPublished - May 21 1979
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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