The HLA A2/6802 supertype is associated with reduced risk of perinatal human immunodeficiency virus type 1 transmission

Kelly S. MacDonald, Kelly S. MacDonald, Nico J.D. Nagelkerke, Jose Castillo, Susie Ramhadin, Simon Njenga, Julius Oyug, Jekoniah Ndinya-Achola, Brian H. Barber, Job J. Bwayo, Francis A. Plummer

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

Certain HLAs may, in part, account for differences in human immunodeficiency virus type 1 (HIV-1) susceptibility by presenting conserved immunogenic epitopes for T cell recognition. The HLA supertype A2/6802 is associated with decreased susceptibility to HIV-1 among sex workers. The alleles in this supertype present the same HIV-1 peptide epitopes for T cell recognition in some cases. This study sought to determine whether the HLA A2/6802 supertype influenced HIV-1 transmission in a prospective cohort of HIV-1-infected mothers and children in Kenya. Decreased perinatal HIV-1 infection risk was strongly associated with possession of a functional cluster of related HLA alleles, called the A2/6802 supertype (odds ratio, 0.12; 95% confidence interval, 0.03-0.54; P = .006). This effect was independent of the protective effect of maternal-child HLA discordance. These data provide further evidence that HLA supertypes are associated with differential susceptibility to HIV-1 transmission.

Original languageEnglish
Pages (from-to)503-506
Number of pages4
JournalJournal of Infectious Diseases
Volume183
Issue number3
DOIs
Publication statusPublished - Feb 1 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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