The epidemiology of Chlamydia trachomatis within a sexually transmitted diseases core group

Robert C. Brunham, Joshua Kimani, Job Bwayo, Gregory Maitha, Ian Maclean, Chunlin Yang, Caixia Shen, Susan Roman, Nico J.D. Nagelkerke, Mary Cheang, Francis A. Plummer

Research output: Contribution to journalArticlepeer-review

124 Citations (Scopus)

Abstract

Female sex workers in Nairobi were prospectively evaluated for risk factors of incident Chlamydia trachomatis infection. Independent risk factors included cervical ectopy (P = .007), gonococcal infection (P = .002), human immunodeficiency virus (HIV) seropositivity (P = .003), HIV seroconversion (P = .001), and duration of prostitution (P = .002). Eighteen different C. trachomatis outer membrane protein (omp1) genotypes were identified, with the allelic composition of the C. trachomatis population changing significantly over time (P = .005). Seventeen of 19 reinfections >6 months apart were with different C. trachomatis omp1 genotypes. Women with HIV infection had an increased proportion of visits with C. trachomatis infection (P = .001) and an increased risk of reinfection (P = .008). Overall, the data demonstrate significant fluctuations in the genotype composition of the C. trachomatis population and a reduced rate of same-genotype reinfection consistent with the occurrence of strain-specific immunity.

Original languageEnglish
Pages (from-to)950-956
Number of pages7
JournalJournal of Infectious Diseases
Volume173
Issue number4
DOIs
Publication statusPublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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