The effects of vitamin B on the immune/cytokine network and their involvement in depression

Kathleen Mikkelsen, Lily Stojanovska, Monica Prakash, Vasso Apostolopoulos

Research output: Contribution to journalReview articlepeer-review

57 Citations (Scopus)

Abstract

Increasing evidence indicates that there are various interactions between the nervous system and the immune system, and that the immune system plays an important role in the pathogenesis of depression. Pro-inflammatory cytokines (such as IL-1, IL-6, TNF-α) have been implicated in the neurobiological manifestations of depression. The immune/cytokine network has a powerful influence on the brain. In addition, deficiency in B vitamins has been linked to depression. Hence, greater knowledge of how immune cells change in the presence of vitamin B derivatives could improve understanding of how immune changes may correlate with depression, all of which are discussed herein.

Original languageEnglish
Pages (from-to)58-71
Number of pages14
JournalMaturitas
Volume96
DOIs
Publication statusPublished - Feb 1 2017
Externally publishedYes

Keywords

  • Depression
  • Immune cells
  • Immune system
  • Inflammation
  • Mental health

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynaecology

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