The effects of vitamin B in depression

Kathleen Mikkelsen, Lily Stojanovska, Vasso Apostolopoulos

Research output: Contribution to journalArticlepeer-review

73 Citations (Scopus)

Abstract

Vitamins are dietary components which are necessary for life. They play a major role in health and their deficiency may be linked to symptoms of psychiatric disorders. B vitamins are required for proper functioning of the methylation cycle, monoamine oxidase production, DNA synthesis and the repair and maintenance of phospholipids. Vitamin B deficiency could influence memory function, cognitive impairment and dementia. In particular, vitamins B1, B3, B6, B9 and B12 are essential for neuronal function and deficiencies have been linked to depression. We discuss the causes of depression and the neurochemical pathways in depression. In particular, we provide evidence that vitamin B contributes to the complexity of depressive symptoms.

Original languageEnglish
Pages (from-to)4317-4337
Number of pages21
JournalCurrent Medicinal Chemistry
Volume23
Issue number38
DOIs
Publication statusPublished - Nov 1 2016
Externally publishedYes

Keywords

  • Depression
  • Vitamin B
  • Vitamin B complex
  • Vitamin B12
  • Vitamin B6

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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