The disposition of theophylline in camels after intravenous administration

Ibrahim A. Wasfi, M. Elghazali, N. S. Boni, A. A.A. Hadi, G. A. Alhadrami, A. M. Almuhrami, N. A. Alkatheeri, I. M. Barezaiq, B. A.O. Agha, S. A. Wajid

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5 Citations (Scopus)

Abstract

The pharmacokinetics of theophylline were determined after an intravenous (i.v.) dose of 2.36 mg/kg in six camels and 4.72 mg/kg body weight in three camels. The data obtained (median and range) for the Low and high dose. respectively, were as follows: the distribution half-lives (t(1/2α)) were 1.37 (0.64-3.25) and 2.66 (0.83-3.5) h, the elimination half-lives (t(1/2β)) were 11.8 (8.25-14.9) and 10.4 (10.0-13.5) h, the steady state volumes of distribution (V(ss)) were 0.88 (0.62-1.54) and 0-76 (0.63-0.76) L/kg, volumes of the central compartment (V(c)) were 0.41 (0.35-0.63) and 0.51 (0.36-0.52) L/kg, total body clearances (Cl(t)) were 62.3 (39.4-97.0) and 50.2 (47.7-67.4) mL/h.kg body weight and renal clearance (V(r)) for the low dose was 0.6 (0.42-0.96) mL/h.kg body weight. There was no significant difference in the pharmacokinetic parameters between the two doses. Theophylline protein binding at a concentration of 5 μg/mL was 32.2 ± 3.3%. Caffeine was identified as a theophylline metabolite but its concentration in serum and urine was small. Based on the pharmacokinetic values obtained in this study, a dosage of 7.5 mg/ kg body weight administered by i.v. injection at 12 h intervals can be recommended. This dosing regimen should achieve an average steady state serum concentration of 10 μg/mL with peak serum concentration not exceeding 15 μg/mL.

Original languageEnglish
Pages (from-to)255-260
Number of pages6
JournalJournal of Veterinary Pharmacology and Therapeutics
Volume22
Issue number4
DOIs
Publication statusPublished - Sep 8 1999

ASJC Scopus subject areas

  • Pharmacology
  • veterinary(all)

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