The development of osteoblasts from stem cells to supplement fusion of the spine during surgery for AIS

H. Jiang, C. Secretan, T. Gao, K. Bagnall, G. Korbutt, J. Lakey, N. M. Jomha

Research output: Chapter in Book/Report/Conference proceedingConference contribution

10 Citations (Scopus)

Abstract

Surgical correction in severe cases of AIS is often hampered by insufficient autograft bone to facilitate the fusion. The development of other sources of bone generating cells would greatly enhance the surgical. Bone marrow derived stem cells were harvested from femoral reaming during total hip arthroplasty for the purpose of differentiating into osteoblasts. Stem cells were isolated from the marrow and successfully differentiated into three cell lines (osteoblasts, chondrocytes and adipocytes) to confirm multilineage potential. Osteoblasts were developed from the stem cells and demonstrated the ability to be cultured to possibly provide a source of bone generating cells to augment surgical fusions. It is anticipated that the addition of osteoblasts created from stem cells (combined with appropriate matrix) will have significant influence on the success of AIS surgery through improvement of bone fusion.

Original languageEnglish
Title of host publicationResearch into Spinal Deformities 5
PublisherIOS Press
Pages467-472
Number of pages6
ISBN (Print)1586036300, 9781586036300
Publication statusPublished - Jan 1 2006
Event6th Biennial Meeting of the International Research Society of Spinal Deformities - Ghent, Belgium
Duration: Jun 21 2006Jun 24 2006

Publication series

NameStudies in Health Technology and Informatics
Volume123
ISSN (Print)0926-9630
ISSN (Electronic)1879-8365

Other

Other6th Biennial Meeting of the International Research Society of Spinal Deformities
Country/TerritoryBelgium
CityGhent
Period6/21/066/24/06

Keywords

  • Adolescent idiopathic scoliosis
  • osteoblasts
  • stem cells
  • surgery

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics
  • Health Information Management

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