The contribution of growth hormone to mammary neoplasia

Jo K. Perry, Kumarasamypet M. Mohankumar, B. Starling Emerald, Hichem C. Mertani, Peter E. Lobie

Research output: Contribution to journalReview articlepeer-review

65 Citations (Scopus)

Abstract

While the effects of growth hormone (GH) on longitudinal growth are well established, the observation that GH contributes to neoplastic progression is more recent. Accumulating literature implicates GH-mediated signal transduction in the development and progression of a wide range malignancies including breast cancer. Recently autocrine human GH been demonstrated to be an orthotopically expressed oncogene for the human mammary gland. This review will highlight recent evidence linking GH and mammary carcinoma and discuss GH-antagonism as a potential therapeutic approach for treatment of breast cancer.

Original languageEnglish
Pages (from-to)131-145
Number of pages15
JournalJournal of Mammary Gland Biology and Neoplasia
Volume13
Issue number1
DOIs
Publication statusPublished - Mar 2008
Externally publishedYes

Keywords

  • Breast cancer
  • Growth hormone
  • Mammary development

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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