The clinical relevance of the tumor marker CA 19-9 in the diagnosing and monitoring of pancratic carcinoma

F. Safi, R. Roscher, H. G. Beger

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

The tumor marker test CA19-9 is based on monoclonal antibody to colonic carcinoma cell lines. In this study, the utility of the tumor marker in the diagnosis of pancreatic carcinoma was evaluated. CA19-9 is strongly expressed in most tissue specimens from pancreatic carcinomas. However, this antigen is also found in normal pancreas and specimens from chronic pancreatitis. CA19-9 is released into the circulation, and was found in increased concentrations (>37 U/ml) in 87% of the patients with pancreatic carcinoma (N=145), as compared with only 13% in the group of patients with benign diseases (N=1081) and 29% of those with extrapancreatic malignancies (N=691). The preoperatively raised CA19-9 concentration in patients with stage I of pancreatic carcinoma decreased after curative resection of the carcinoma to values within normal range. However, in no CA19-9 estimation following a palliative surgical intervention of stage III and IV patients or in cases of inoperable carcinomas was a serum concentration of less than 37 U/ml recorded. The mean survival rate of stage I patients was 29 months, whereas it was only 6 months for stage III, IV and patients with inoperable carcinomas.

Original languageEnglish
Pages (from-to)83-91
Number of pages9
JournalBulletin du Cancer
Volume77
Issue number1
Publication statusPublished - Jan 1 1990

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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