dl‐3‐Arsonoalanine has been synthesized by the Strecker synthesis from the unstable compound arsonoacetaldehyde. It inactivates pig heart cytosolic aspartate aminotransferase and inhibits aspartate ammonia‐lyase by competing with aspartate (Ki/Km 0.23). The fumarate analogue (E)‐3‐arsonoacrylic acid and the malate analogue (RS)‐3‐arsonolactate also inhibit fumarate hydratase, competing with fumarate (Ki/Km 1.8) and malate (Ki/Km 1.6) respectively. Attempted non‐enzymic transamination of 3‐arsonoalanine gave elimination of arsenite, in contrast with the transamination of 3‐phosphonoalanine, which is either successful or leads to loss of phosphate.
|Number of pages||6|
|Journal||European Journal of Biochemistry|
|Publication status||Published - Jul 1993|
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