Synthesis and evaluation of antibacterial and antifungal activities of 1,3-disubstituted-4-thioxoimidazolidin-2-one derivatives

Marwa A.M.Sh El-Sharief, Samir Y. Abbas, Ziad Moussa, Eman W. El-Gammal, Ahmed M.Sh El-Sharief

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

1,3-Disubstituted-4-thioxoimidazolidin-2-one derivatives with various substituents at N 1 and N 3 were synthesized with high yields and excellent purity by the reaction of various N-arylcyanothioformamide derivatives with isocyanate derivatives. The activity of these products as antibacterial and antifungal agents was studied to through some light on structural activity relationship. Some of synthesized compounds showed significant antibacterial and antifungal activities. Most of the imidazole derivatives possess significant antifungal activity aginst S. cerevisiae(MIC 1–10 µg mL –1 ). As comparision with ketoconazole, most of the imidazole derivatives showed activity ranging from 50 % less activity to fourfold activity.

Original languageEnglish
Pages (from-to)335-340
Number of pages6
JournalCroatica Chemica Acta
Volume91
Issue number3
DOIs
Publication statusPublished - 2018
Externally publishedYes

Keywords

  • Antimicrobial activity
  • Imidazolidineiminothiones
  • Isocyanates
  • N-arylcyanothioformamides

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint

Dive into the research topics of 'Synthesis and evaluation of antibacterial and antifungal activities of 1,3-disubstituted-4-thioxoimidazolidin-2-one derivatives'. Together they form a unique fingerprint.

Cite this