Synthesis and antitumor activity of 5-trifluoromethyl-2,4-dihydropyrazol-3- one nucleosides

Ibrahim M. Abdou, Ayman M. Saleh, Hussein F. Zohdi

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

2,4-Dihydropyrazole glucosides 3a-3c were prepared and tested for their antitumor activity. The structures of these compounds were established by 1H and 13C-NMR spectroscopy. Glucoside 3b shows an in vitro IC50 value of 16.4 μM against proliferation of the human promyelotic leukemia (HL60) cell line.

Original languageEnglish
Pages (from-to)109-116
Number of pages8
JournalMolecules
Volume9
Issue number3
DOIs
Publication statusPublished - Mar 2004

Keywords

  • Antitumor agents
  • Glucopyranose
  • Trifluoromethylpyrazole

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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