Synthesis and antimicrobial activity of new 1,2,4-triazole-3-thiol metronidazole derivatives

Haythem A. Saadeh, Ibrahim M. Mosleh, Amal G. Al-Bakri, Mohammad S. Mubarak

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

New 1,2,4-triazole-3-thiol metronidazole derivatives have been synthesized by treating 1,2,4-triazole-3-thiols with metronidazole tosylate (toluene-4-sulfonic acid 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl ester) in DMF and in the presence of potassium carbonate as a base. S-alkylated and N-alkylated products were obtained, with the S-alkylated being the major products. All of the newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, and high-resolution mass spectrometry. The antiparasitic activity of the compounds against Entamoeba histolytica and Giardia intestinalis was investigated. The antibacterial and antifungal activity of the compounds, assessed as minimal inhibitory concentration, was also investigated.

Original languageEnglish
Pages (from-to)471-478
Number of pages8
JournalMonatshefte fur Chemie
Volume141
Issue number4
DOIs
Publication statusPublished - Apr 2010
Externally publishedYes

Keywords

  • Antimicrobial activity
  • Antiparasitic activity
  • Metronidazole
  • Triazoles

ASJC Scopus subject areas

  • Chemistry(all)

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