Synthesis and antimicrobial activity of 4-trifluoromethylpyridine nucleosides

Shaikha S. Alneyadi, Anas A. Abdulqader, Alaa A. Salem, Ibrahim M. Abdou

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

4-Trifluoromethylpyridine derivatives 4-8 represent good candidates for the discovery of new antibacterial agents. Fluorinated pyridine nucleosides 4-7 and non-nucleoside analogues 8a,b were synthesized and evaluated for their antibacterial activities against Staphylococcus aureus, Bacillus infantis, Escherichia coli and Stenotrophomonas maltophilia. The minimum inhibitory concentrations (MICs) of the new nucleosides 4-7 range from 1.3 to 4.9 μg/mL and MICs of fluoroaryl derivatives 8a,b are in the range of 1.8-5.5 μg/mL. Activity of amoxicillin, the reference drug, is 1.0-2.0 μg/mL under similar conditions.

Original languageEnglish
Pages (from-to)197-203
Number of pages7
JournalHeterocyclic Communications
Volume23
Issue number3
DOIs
Publication statusPublished - Jun 2017

Keywords

  • Antimicrobial
  • Fluoropyridine
  • Nucleosides
  • Synthesis
  • gHMBC

ASJC Scopus subject areas

  • Organic Chemistry

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