Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis

Maria Serra-Blasco, Joaquim Radua, Carles Soriano-Mas, Alba Gómez-Benlloch, Daniel Porta-Casteràs, Marta Carulla-Roig, Anton Albajes-Eizagirre, Danilo Arnone, Paul Klauser, Eric J. Canales-Rodríguez, Kevin Hilbert, Toby Wise, Yuqui Cheng, Sevdalina Kandilarova, David Mataix-Cols, Eduard Vieta, Esther Via, Narcís Cardoner

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.

Original languageEnglish
Pages (from-to)269-281
Number of pages13
JournalNeuroscience and Biobehavioral Reviews
Volume129
DOIs
Publication statusPublished - Oct 2021

Keywords

  • Anxiety disorders
  • Comorbidities
  • Gray matter volume
  • Major depressive disorder
  • Meta-analysis
  • Neuropsychiatry
  • Posttraumatic stress disorder
  • Structural neuroimaging

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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