Somatostatin and the dumping syndrome

R. G. Long, T. E. Adrian, S. R. Bloom

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Infusion of somatostatin reduced the symptoms of the early dumping syndrome after oral glucose was given and also reduced the associated tachycardia and rise in packed cell volume. It inhibited the secretion of enteroglucagon, neurotensin, and vasoactive intestinal polypeptide, which are raised in patients with the dumping syndrome and may have an aetiological role. It also prevented the reactive hypoglycaemia of late dumping by inhibiting the release of gastric inhibitory polypeptide and insulin. Somatostatin, possibly through its inhibitory effects on hormonal secretion, may have a role in the management of patients with the early and late dumping syndrome.

Original languageEnglish
Pages (from-to)886-888
Number of pages3
JournalBritish Medical Journal (Clinical research ed.)
Volume290
Issue number6472
DOIs
Publication statusPublished - Mar 23 1985
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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