Simultaneous determination of cadmium, mercury, lead, arsenic, copper, and zinc in human breast milk by ICP-MS/microwave digestion

Melita Kosanovic, Abdu Adem, Milan Jokanovic, Yousef M. Abdulrazzaq

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

An analytical method using microwave digestion and inductively coupled argon plasma-mass spectrometry (ICP-MS) analysis was developed for the measurement of Cd, Hg, Pb, As, Cu, and Zn in human breast milk. We applied external calibration, internal calibration, and standard addition for reference material and pooled milk analysis. Method performances were defined in terms of detection limits, accuracy, and precision. Accuracy varied between 93% and 105% and precision between 3% and 8%. External calibration and background interferences were checked through a calibrator addition procedure. Our method has shown high accuracy, precision, and sensitivity, as well as linearity within a wide range of values. Our methodology, developed by treatment of reference material and pooled milk samples, was applied for determination of Cu, Zn, As, Cd, Hg, and Pb in 120 human breast milk samples.

Original languageEnglish
Pages (from-to)406-416
Number of pages11
JournalAnalytical Letters
Volume41
Issue number3
DOIs
Publication statusPublished - Feb 2008

Keywords

  • Arsenic
  • Cadmium
  • Copper
  • Human milk
  • ICP-MS
  • Lead
  • Mercury
  • Microwave digestion
  • Toxic
  • Trace elements
  • Zinc

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Spectroscopy
  • Clinical Biochemistry
  • Biochemistry, medical
  • Electrochemistry

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