Simian immunodeficiency virus-specific cytotoxic T-lymphocyte induction through DNA vaccination of rhesus monkeys

Yasuhiro Yasutomi, Harriet L. Robinson, Shan Lu, Farah Mustafa, Christine Lekutis, James Arthos, James I. Mullins, Gerald Voss, Kelledy Manson, Michael Wyand, Norman L. Letvin

Research output: Contribution to journalArticlepeer-review

124 Citations (Scopus)

Abstract

In view of the growing evidence that virus-specific cytotoxic T lymphocytes (CTL) play an important role in containing the early spread of human immunodeficiency virus type 1 (HIV-1) in infected individuals, novel vaccine strategies capable of eliciting HIV-1-specific CTL are being pursued in attempts to create an effective AIDS vaccine. We have used the simian immunodeficiency virus of macaques (SIVmac)/rhesus monkey model to explore the induction of AIDS virus-specific CTL responses by DNA vaccination. We found that the inoculation of rhesus monkeys with plasmid DNA encoding SIVmac Env and Gag elicited a persisting SIVmac-specific memory CTL response. These CTL were CD8+ and major histocompatibility complex class I restricted. These studies provide evidence for the potential utility of DNA inoculation as an approach to an HIV-1 vaccine.

Original languageEnglish
Pages (from-to)678-681
Number of pages4
JournalJournal of Virology
Volume70
Issue number1
DOIs
Publication statusPublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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