Sequential flow‐injection potentiometric determination of iodide and iodine in povidone iodine pharmaceuticals

Saad S M Hassan, Sayed A M Marzouk

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

A potentiometric sensor‐based flow‐injection system for determining iodide is described. The system utilizes a flow‐through sandwich cell and incorporates iron (II)‐tris bathophenanthroline iodide ion pair complex as an exchange site in a PVC matrix membrane. The sensor displays a fast response for 10−1 to 10−6 M iodide ion with an anionic slope of 59.1 ± 0.3 mV/concentration decade over the pH range 1 to 11. The experimental setup offers a precise, sensitive, selective and high sample throughput technique for determining iodide and iodine over a wide range of concentration. The limit of detection is 0.5 ppm iodide in a 20 μL sample. The average recovery is 99.8%, and the mean standard deviation is 0.5%. Sequential flow‐injection determination of iodide and iodine in some pharmaceutical preparations containing povidone iodine is performed by sample injection in a sodium sulfate‐ascorbic acid stream and monitoring of the total iodide equivalent to I and I2. This is followed by injection of a second sample in an alkaline resorcinol stream and measuring of the iodide equivalent to I and 1/2 I2. Iodine and iodide concentrations are calculated from the consecutive signals. The method gives results in good agreement with those obtained by the United States Pharmacopeia.

Original languageEnglish
Pages (from-to)855-861
Number of pages7
JournalElectroanalysis
Volume5
Issue number9-10
DOIs
Publication statusPublished - 1993
Externally publishedYes

Keywords

  • Flow‐injection analysis
  • Iodide PVC sensor
  • Iron (II) bathophenanthroline iodide membrane
  • Pharmaceutical analysis
  • Potentiometry
  • Povidone iodine
  • Sequential determination of iodine and iodide

ASJC Scopus subject areas

  • Analytical Chemistry
  • Electrochemistry

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