Semi-empirical Modeling for DNA Bases via Z-shaped Graphene Nanoribbon with a Nanopore

Asma Wasfi, Falah Awwad

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

DNA base detection is a vastly advancing technology to obtain the bases sequence in human genome thus allowing for recognition and medication of disease. Acquiring reliable, quick, and cheap DNA sequencing facilitates personalized medicine procedure where right medication will be given to patients. In this article, a semi-empirical model is presented for calculating electron transport properties for the z-shaped sensor to identify the DNA sequence. The z-shaped sensor is made of two metallic electrodes of zigzag graphene nanoribbon (ZGNR) connected through a semiconducting channel with a pore in the middle where DNA bases are translocated. The channel is made of armchair graphene nanoribbon (AGNR) which is semiconducting. Semi-empirical model and non-equilibrium Green's function are utilized to ananlyze the various electronic characteristics. The semi-empirical model used is an expansion of the extended Hückel technique with self-consistent Hartree potential. Using the non-equilibrium Green's function combined with self-consistent extended Hückel (NEGF+SC-EH), we show that each of the bases placed within the pore whose edge carbon atoms are passivated with nitrogen leads to a unique current. Several electronic properties are studied such as electrical current and transmission spectrum of DNA bases within the sensor's nanopore. These characteristics are investigated with modification of base orientation. Our study produced unique current for each of the DNA bases inside the pore.

Original languageEnglish
Title of host publication2019 IEEE 13th International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2019
PublisherIEEE Computer Society
Pages16-21
Number of pages6
ISBN (Electronic)9781728166483
DOIs
Publication statusPublished - Nov 2019
Event13th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2019 - Gwangju, Korea, Republic of
Duration: Nov 21 2019Nov 24 2019

Publication series

NameIEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED
Volume2020-November
ISSN (Print)2159-6964
ISSN (Electronic)2159-6972

Conference

Conference13th IEEE International Conference on Nano/Molecular Medicine and Engineering, NANOMED 2019
Country/TerritoryKorea, Republic of
CityGwangju
Period11/21/1911/24/19

ASJC Scopus subject areas

  • Molecular Medicine
  • Biomedical Engineering
  • Microbiology (medical)

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