Self-reported diseases and the risk of non-vertebral fractures: The Tromsø study

Luai A. Ahmed, Henrik Schirmer, Gro K. Berntsen, Vinjar Fønnebø, Ragnar M. Joakimsen

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

We wanted to estimate the independent fracture risk associated with chronic diseases for men and women separately, adjusting for other known risk factors. This is a population-based study of all those who attended the fourth survey (1994-1995) in the Tromsø Study (n = 27,159) who were followed until 31 December 2000 with respect to non-vertebral fractures. At baseline the age range was 25-98 years. Chronic disease cases were defined by self-report in questionnaires. All non-vertebral fractures were registered by computerized search in radiographic archives in the sole provider of radiographic service in the area. A total of 446 and 803 non-vertebral fractures were registered among men and women, respectively. Self-reported diabetes mellitus, stroke, asthma, hypo- and hyperthyroidism and psychiatric disorders were associated with increased fracture risk. Multivariate analyses showed an independent risk of fractures associated with self-reported diabetes mellitus, hypothyroidism and psychiatric disorders among men. Among women the independent risk was associated with self-reported asthma, hypo- and hyperthyroidism and psychiatric disorders. Self-reported heart disease had a protective effect on wrist fracture, especially in women. Increased burden of chronic diseases increase the risk of all non-vertebral (P < 0.0001), wrist (P = 0.005), proximal humerus (P = 0.0004) and hip fracture (P = 0.0002) in men, and for the proximal humerus (P = 0.003) and hip fracture (P = 0.04) in women. There was an independent fracture risk associated with self-reported diabetes mellitus, asthma, hypo- and hyperthyroidism and psychiatric disorders in men and women. Increasing burden of disease increased fracture risk in both men and women.

Original languageEnglish
Pages (from-to)46-53
Number of pages8
JournalOsteoporosis International
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2006
Externally publishedYes

Keywords

  • Chronic disease
  • Independent fracture risk
  • Non-vertebral fractures
  • Risk of fracture

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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