Selective Deposition of Pulsed Charged Aerosols in the Human Lung

A. H. Hashish, A. G. Bailey, T. J. Williams

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

The charged, pulsed aerosol technique has the advantage that the inspired aerosol can be delivered efficiently to sites of interest within the lung, and that the exposure time of an airway to the aerosol pulse can be controlled. Our existing mathematical lung deposition model has been extended to deal with charged, pulsed aerosols, and to lung morphologies where bronchoconstriction is present. For a given pulse volume, deposition is enhanced by increasing the level of particle charge and duration of the breath-holding pause. This technique can be used to assist in the “targeting” of therapeutic or other agents on to different sites within a normal or diseased lung and for designing and optimizing clinical procedures.

Original languageEnglish
Pages (from-to)167-171
Number of pages5
JournalJournal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung
Volume7
Issue number2
DOIs
Publication statusPublished - Jan 1 1994
Externally publishedYes

Keywords

  • Bronchoconstriction
  • Drug delivery
  • Particle charge
  • Pulsed aerosol

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology (medical)

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