Seabuckthorn attenuates cardiac dysfunction and oxidative stress in isoproterenol-induced cardiotoxicity in rats

Salma Malik, Sameer Goyal, Shreesh Kumar Ojha, Saurabh Bharti, Saroj Nepali, Santosh Kumari, Virendra Singh, Dharamvir Singh Arya

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

We investigated the effects of seabuckthorn (SBT) oil in isoproterenol (ISO)-induced cardiotoxicity with reference to hemodynamic, antioxidant, histopathological, and ultrastructural parameters. Rats were administered SBT oil (5, 10, and 20 mL/kg per d) or vehicle orally for 30 days along with ISO (85 mg/kg, subcutaneously, at 24-hour interval) on 29th and 30th day. On 31st day, ISO control rats showed cardiac dysfunction, increased lipid peroxidation, depletion of cardiac injury marker enzymes, and antioxidant activities. Myocardial necrosis, edema, and inflammation were evident from the light microscopic and ultrastructural changes. Seabuckthorn oil at the dose of 20 mL/kg per d significantly modulates hemodynamic and antioxidant derangements. The preventive role of SBT oil on ISO-induced cardiotoxicity was reconfirmed by histopathological and ultrastructural examinations. Thus, the present study reveals that SBT oil mitigates myocardial damage in ISO-induced cardiac injury in rats by maintaining hemodynamic, biochemical, histopathological, and ultrastructural perturbations owing to its free radical scavenging and antioxidant activities.

Original languageEnglish
Pages (from-to)671-680
Number of pages10
JournalInternational Journal of Toxicology
Volume30
Issue number6
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

Keywords

  • Antioxidant
  • Hemodynamic
  • Hippophae rhamnoides
  • Isoproterenol
  • Myocardial infarction

ASJC Scopus subject areas

  • Toxicology

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