Role of the nervous system in cancer metastasis

Nyanbol Kuol, Lily Stojanovska, Vasso Apostolopoulos, Kulmira Nurgali

Research output: Contribution to journalReview articlepeer-review

67 Citations (Scopus)

Abstract

Cancer remains as one of the leading cause of death worldwide. The development of cancer involves an intricate process, wherein many identified and unidentified factors play a role. Although most studies have focused on the genetic abnormalities which initiate and promote cancer, there is overwhelming evidence that tumors interact within their environment by direct cell-to-cell contact and with signaling molecules, suggesting that cancer cells can influence their microenvironment and bidirectionally communicate with other systems. However, only in recent years the role of the nervous system has been recognized as a major contributor to cancer development and metastasis. The nervous system governs functional activities of many organs, and, as tumors are not independent organs within an organism, this system is integrally involved in tumor growth and progression.

Original languageEnglish
Article number5
JournalJournal of Experimental and Clinical Cancer Research
Volume37
Issue number1
DOIs
Publication statusPublished - Jan 15 2018
Externally publishedYes

Keywords

  • Cancer
  • Metastasis
  • Neuro-cancer interaction
  • Neuropeptides
  • Neurotransmitters

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint

Dive into the research topics of 'Role of the nervous system in cancer metastasis'. Together they form a unique fingerprint.

Cite this