Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs

Benoit Moreaux, Abderrahim Nemmar, Grégoire Vincke, David Halloy, Dominique Beerens, Charles Advenier, Pascal Gustin

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

The purpose of this work was to investigate the role of tachykinins in cough induced by citric acid (0.8 M) in pigs. With this object, we have studied the effect of citric acid on substance P content in the tracheo-bronchial tree and the effects of substance P and of tachykinin receptor antagonists on citric acid-induced cough. Citric acid exposure significantly increased substance P concentration in both broncho-alveolar and tracheal lavage fluids, while it decreased significantly the substance P content in tracheal mucosa. Substance P did not elicit cough, but significantly potentiated the citric acid-induced cough frequency. Tachykinin NK1, NK2 or NK3 receptor antagonists, SR 140333 (nolpitantium), SR 48968 (saredutant) and SR 142801 (osanetant), respectively, significantly inhibited citric acid-induced cough. The same inhibitory effect of tachykinin receptor antagonists was observed, when substance P was nebulised before citric acid challenge. We conclude that citric acid induces in pigs a release of substance P in the tracheo-bronchial tree, which plays a sensitising role on the cough reflex. The involvement of tachykinin NK1, NK2, NK3 receptors are also demonstrated in this reflex. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)305-312
Number of pages8
JournalEuropean Journal of Pharmacology
Volume408
Issue number3
DOIs
Publication statusPublished - Nov 24 2000
Externally publishedYes

Keywords

  • C-fibre
  • Citric acid
  • Cough
  • Substance P
  • Tachykinin

ASJC Scopus subject areas

  • Pharmacology

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