Role of nitric oxide in inflammation

F. S. Laroux, K. P. Pavlick, I. N. Hines, S. Kawachi, H. Harada, S. Bharwani, J. M. Hoffman, M. B. Grisham

Research output: Contribution to journalReview articlepeer-review

161 Citations (Scopus)

Abstract

A number of laboratories have sought to elucidate the role of nitric oxide (NO) in both acute and chronic inflammatory diseases. It is now well appreciated that NO can influence many aspects of the inflammatory cascade ranging from its own expression to recruitment of leucocytes to the effected tissue. With the advent of mice selectively deficient in the various isoforms of nitric oxide synthase (NOS), the role that NO may play in various disease states can now be examined in vivo. One such syndrome that has gained much attention in recent years is ischaemia and reperfusion-induced tissue injury. Ischaemia-reperfusion (I/R) injury is an important clinical consideration in situations such as transplantation, trauma, liver or bowel resection and haemorrhagic shock. A hallmark of I/R is the production of reactive oxygen species (ROS) during the reperfusion phase and it is thought that the production of ROS mediate much of the post-ischaemic tissue injury. This review will examine the current state of knowledge regarding the regulatory mechanisms by which NO can influence various aspects of the inflammatory cascade as well as its role in a model of I/R injury in vivo.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalActa Physiologica Scandinavica
Volume173
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Ischaemia
  • Liver
  • NF-κB
  • Nitric oxide

ASJC Scopus subject areas

  • Physiology

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