Review findings included diminished coronary flow reserve after surgery in children with congenital heart disease and inflammation

Erkki Pesonen, Petru Liuba, Elhadi H. Aburawi

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Aim: The aim of this review was to develop a deeper knowledge of the physiology of coronary blood flow and coronary flow reserve in young patients with congenital heart disease and inflammatory diseases. Methods: We searched for papers published in English on coronary blood flow and coronary flow reserve using the PubMed and Google search databases. This identified 42 papers extending back to 1976 and a book from 2008 (Davis et al. Microcirculation. Boston, MA: Elsevier, 2008: 161–284). Results: Our review showed that the implications of coronary blood flow and coronary flow reserve in paediatric patients with congenital heart disease and inflammatory diseases are still not fully understood. However, a key finding was that coronary flow reserve was diminished in patients with congenital heart disease and inflammation after surgery, with or without a cardiopulmonary bypass. Other findings discussed by this review relate to volume and pressure overload in acyanotic congenital heart disease, reduced myocardial perfusion and cyanotic congenital heart disease. Conclusion: We still have much to discover about paediatric patients with congenital heart disease and inflammatory diseases. Understanding the pathophysiology of coronary blood flow could help the postoperative treatment of such patients.

Original languageEnglish
Pages (from-to)218-223
Number of pages6
JournalActa Paediatrica, International Journal of Paediatrics
Volume108
Issue number2
DOIs
Publication statusPublished - Feb 2019

Keywords

  • Congenital heart disease
  • Coronary blood flow
  • Coronary flow reserve
  • Doppler echocardiography
  • Endothelial cell dysfunction
  • Paediatric coronary flow

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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