Responses of arterial smooth muscle from normotensive and pre-eclamptic subjects to the calcium channel agonist, Bay K 8644

A. B. Ebeigbe, M. Ezimokhai, C. P. Aloamaka

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

The effect of Bay K 8644, a dihydropyridine Ca2+ agonist, on in vitro contractile responses of inferior epigastric arteries from normotensive (N) and pre-eclamptic (P) subjects has been investigated, with a view to further defining the mechanism of the increased vascular sensitivity associated with pregnancy-induced hypertension. Bay K 8644 (10-10-10-7M) caused dose-dependent contractions of N as well as P arteries under resting conditions in the order: P > N and caused development of rhythmic contractions in both N and P arteries. Bay K 8644 effects were prevented by 3 × 10-8M Nifedipine (a Ca+2 antagonist). Bay K 8644 also significantly (P < 0.05) enhanced the sensitivity as well as maximal contractile responses to CaCl2 in 40 m M K+-depolarized Ca-depleted N and P arteries in the order: P > N. The results suggest that the increased peripheral vascular sensitivity associated with pregnancy-induced hypertension may be due, at least in part, to enhanced activity of the potential-sensitive Ca2+ channels in arterial smooth muscle plasmalemma.

Original languageEnglish
Pages (from-to)461-468
Number of pages8
JournalResearch in Experimental Medicine
Volume187
Issue number6
DOIs
Publication statusPublished - Nov 1 1987

Keywords

  • Bay K 8644
  • Ca channel
  • Epigastric artery
  • Pre-eclampsia
  • Smooth muscle

ASJC Scopus subject areas

  • Medicine(all)

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