Response of plasma pancreatic and gastrointestinal hormones and growth hormone to oral and intravenous glucose and insulin hypoglycaemia in Chagas disease

R. G. Long, R. H. Albuquerque, A. Prata, A. J. Barnes, T. E. Adrian, N. D. Christofides, S. R. Bloom

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Plasma hormonal responses to insulin hypoglycaemia and to oral and intravenous glucose were investigated in chagasic patients with severe bowel disease and compared with controls matched for age, sex, weight, and race. After intravenous insulin, plasma concentrations of pancreatic glucagon and pancreatic polypeptide (PP) were reduced in the patients with Chagas disease. These subjects also showed a subnormal rise in plasma insulin after oral glucose. Other hormone responses did not differ significantly from those in the normal controls. These results are compatible with partial denervation of the pancreatic alpha, beta, and PP cells in patients with chronic gastrointestinal Chagas disease.

Original languageEnglish
Pages (from-to)772-777
Number of pages6
JournalUnknown Journal
Volume21
Issue number9
DOIs
Publication statusPublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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