Repair of Oxidative DNA Damage in Saccharomyces cerevisiae

Jisha Chalissery, Deena Jalal, Zeina Al-Natour, Ahmed H. Hassan

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)

Abstract

Malfunction of enzymes that detoxify reactive oxygen species leads to oxidative attack on biomolecules including DNA and consequently activates various DNA repair pathways. The nature of DNA damage and the cell cycle stage at which DNA damage occurs determine the appropriate repair pathway to rectify the damage. Oxidized DNA bases are primarily repaired by base excision repair and nucleotide incision repair. Nucleotide excision repair acts on lesions that distort DNA helix, mismatch repair on mispaired bases, and homologous recombination and non-homologous end joining on double stranded breaks. Post-replication repair that overcomes replication blocks caused by DNA damage also plays a crucial role in protecting the cell from the deleterious effects of oxidative DNA damage. Mitochondrial DNA is also prone to oxidative damage and is efficiently repaired by the cellular DNA repair machinery. In this review, we discuss the DNA repair pathways in relation to the nature of oxidative DNA damage in Saccharomyces cerevisiae.

Original languageEnglish
Pages (from-to)2-13
Number of pages12
JournalDNA Repair
Volume51
DOIs
Publication statusPublished - Mar 1 2017

Keywords

  • Base excision repair
  • Mitochondrial DNA
  • Oxidative DNA damage
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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