2,4-Dichloro-6-phenylpyrimidine (3) and 2-chloro-4-(1′, 3′dithian2′-yl)pyrimidine (7) were prepared using organolithium reagents. Nucleophilic attack on pyrimidines 1, 3 and 9 using N-methylpiperazine was shown to be highly regioselective, favouring the formation of C-4 substituted products. Reaction of 7 with N,N-dimethylethylenediamine afforded 8 exclusively.
- Nucleophilic substitution
ASJC Scopus subject areas