REGIONALE CHEMOTHERAPIE VON LEBERMETASTASEN KOLOREKTALER KARZINOME. INTRAARTERIELLE VERSUS INTRAVENOSE PLUS INTRAARTERIELLE THERAPIE

Translated title of the contribution: Regional chemotherapy for hepatic metastases: Intraarterial compared with intravenous plus intraarterial treatment

F. Safi, R. Roscher, R. Bitter, K. A. Schumacher, W. Gaus, H. G. Beger

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Regional chemotherapy with floxuridine was undertaken in 50 patients (32 men and 18 women, mean age 57 years) with colorectal carcinoma with metastases only to the liver. In 25 patients (group I) the drug (0.2 mg/kg) was administered exclusively intraarterially into the hepatic artery, while in the remaining 25 (group II) it was given both intraarterially (0.21 mg/kg) and intravenously (0.09 mg/kg) via the inferior vena cava. The remission rate in group I was 56% (14 of 25), in group II it was 64% (16 of 25). It was subsequently discovered that 4 of the 25 in group II already had extrahepatic metastases at the time of implantation of the infusion catheter. The difference in remission rate between the two groups is not significant. Extrahepatic tumour recurrence occurred after a median period of 16 months in 17 patients of group I (68%) and six of 21 of group II (29%, P < 0.01). Over an observation period of 34 months the survival rates of the two groups were not significantly different. However, these results suggest that over a longer period a higher survival rate is to be expected for the intraarterially plus intravenously treated group.

Translated title of the contributionRegional chemotherapy for hepatic metastases: Intraarterial compared with intravenous plus intraarterial treatment
Original languageGerman
Pages (from-to)1478-1483
Number of pages6
JournalDeutsche Medizinische Wochenschrift
Volume114
Issue number39
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Regional chemotherapy for hepatic metastases: Intraarterial compared with intravenous plus intraarterial treatment'. Together they form a unique fingerprint.

Cite this