Ranatuerin 1T: An antimicrobial peptide isolated from the skin of the frog, Rana temporaria

Jadvinder Goraya, Floyd C. Knoop, J. Michael Conlon

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A peptide, termed ranatuerin 1T, with growth-inhibiting activity toward Staphylococcus aureus, was isolated from an extract of the skin of the European brown frog, Rana temporaria. The primary structure of the peptide was established as: GLLSGLKKVG10 KHVAKNVAVS20LMDSLKCKIS30GDC. In common with other anti-microbial peptides from Ranid frogs, (e.g., ranalexin, ranatuerins, gaegurins, brevinins, esculetins, rugosins), ranatuerin IT contains an intramolecular disulfide bridge forming a heptapeptide ring but there is little structural similarity outside this cyclic region. The minimum inhibitory concentration (MIC) of ranatuerin 1T was 120 μM against the Gram- positive bacterium S, aureus and 40 μM against the Gram-negative bacterium Escherichia coli, but the peptide was not active against the yeast Candida albicans.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalPeptides
Volume20
Issue number2
DOIs
Publication statusPublished - Feb 1999
Externally publishedYes

Keywords

  • Anti-microbial peptide
  • Brevenin
  • Esculetin
  • Gaegurin
  • Ranalexin
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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