Quantitative autoradiography of nicotinic receptors in large cryosections of human brain hemispheres

Abdu Adem, Agneta Nordberg, Sukhwinder S. Jossan, Vicki Sara, Per Göran Gillberg

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

In vitro quantitative autoradiography was used to visualize nicotinic receptors in large cryosections of human brain hemispheres. Sections 80 μm thick of human brain hemispheres were incubated with (-)-[3H]nicotine and the distribution of nicotinic receptors in human brain was studied. Increasing numbers of nicotinic binding sites were observed in the: hippocampus < cortex < cerebellum < substantia nigra < putamen < periaqueductal gray. The cartography of nicotinic receptors in the normal human brain will hopefully be of use in the study of the alteration of these receptors in diseased brain.

Original languageEnglish
Pages (from-to)247-252
Number of pages6
JournalNeuroscience Letters
Volume101
Issue number3
DOIs
Publication statusPublished - Jul 3 1989
Externally publishedYes

Keywords

  • Brain hemisphere
  • Human brain
  • Image analysis
  • Large cryosection
  • Nicotine
  • Nicotinic receptor
  • Quantitative autoradiography

ASJC Scopus subject areas

  • Neuroscience(all)

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