Primary Structure and Tissue Distribution of Guinea Pig Gastrin‐Releasing Peptide

C. Shaw, L. Thim, J. M. Conlon

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Abstract: The primary structure of gastrin‐releasing peptide from the guinea pig stomach has been determined by automated Edman degradation and shown to be identical to porcine gastrin‐releasing peptide. Extracts of guinea pig brain and small intestine contained both gastrin‐releasing peptide and its COOH‐terminal decapeptide (neuromedin C) but the stomach extracts contained only gastrin‐releasing peptide. Within the small intestine, highest concentrations of gastrin‐releasing peptide‐like immunoreactivity were found in extracts of the circular and longitudinal smooth muscle layers.

Original languageEnglish
Pages (from-to)1348-1354
Number of pages7
JournalJournal of Neurochemistry
Volume49
Issue number5
DOIs
Publication statusPublished - Nov 1987
Externally publishedYes

Keywords

  • Edman degradation
  • Gastrin‐releasing peptide
  • Guinea pig gastrointestinal tract
  • Neuromedin C

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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