Polygenic expression of somatostatin in lamprey

Stacia A. Sower, Y. C. Chiang, J. M. Conlon

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

Previous studies have led to the identification of three biosynthetically related molecular forms of somatostatin (somatostatin-14, -34 and -37) from the pancreas of the sea lamprey (Petromyzon marinus). We have now isolated from the brain of the same species a second form of somatostatin-14 that is identical to mammalian somatostatin-14 and differs from lamprey pancreatic somatostatin-14 by the substitution Ser12 to Thr. Larger forms of somatostatin were not identified in lamprey brain in this study. These data suggest that the two molecular forms of lamprey somatostatin-14 are the products of different genes that are expressed in a tissue-specific manner.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalPeptides
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 1994
Externally publishedYes

Keywords

  • Agnathan
  • Lamprey brain
  • Posttranslational processing
  • Somatostatin

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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