Plant-Derived Agents for Counteracting Cisplatin-Induced Nephrotoxicity

Shreesh Ojha, Balaji Venkataraman, Amani Kurdi, Eglal Mahgoub, Bassem Sadek, Mohanraj Rajesh

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)

Abstract

Cisplatin (CSP) is a chemotherapeutic agent commonly used to treat a variety of malignancies. The major setback with CSP treatment is that its clinical efficacy is compromised by its induction of organ toxicity, particular to the kidneys and ears. Despite the significant strides that have been made in understanding the mechanisms underlying CSP-induced renal toxicity, advances in developing renoprotective strategies are still lacking. In addition, the renoprotective approaches described in the literature reveal partial amelioration of CSP-induced renal toxicity, stressing the need to develop potent combinatorial/synergistic agents for the mitigation of renal toxicity. However, the ideal renoprotective adjuvant should not interfere with the anticancer efficacy of CSP. In this review, we have discussed the progress made in utilizing plant-derived agents (phytochemicals) to combat CSP-induced nephrotoxicity in preclinical studies. Furthermore, we have also presented strategies to utilize phytochemicals as prototypes for the development of novel renoprotective agents for counteracting chemotherapy-induced renal damage.

Original languageEnglish
Article number4320374
JournalOxidative medicine and cellular longevity
Volume2016
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Biochemistry
  • Ageing
  • Cell Biology

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