Perioperative anti-infective prophylaxis with teicoplanin compared to cephalosporins in orthopaedic and vascular surgery involving prosthetic material

K. Z. Vardakas, E. S. Soteriades, S. A. Chrysanthopoulou, P. J. Papagelopoulos, Matthew E. Falagas

Research output: Contribution to journalEditorialpeer-review

15 Citations (Scopus)

Abstract

A meta-analysis of randomised controlled trials evaluated the effectiveness and safety of teicoplanin compared to first- or second-generation cephalosporins for perioperative anti-infective prophylaxis in orthopaedic and vascular surgery involving prosthetic material. No differences were found between teicoplanin and cephalosporins with respect to the development of infection at the site of surgery or in remote areas of the body. In addition, there were no significant differences in reported adverse effects or mortality. These findings indicate that both regimens are equally effective in preventing post-operative infections in orthopaedic and vascular surgery involving prosthetic materials.

Original languageEnglish
Pages (from-to)775-777
Number of pages3
JournalClinical Microbiology and Infection
Volume11
Issue number10
DOIs
Publication statusPublished - Oct 2005
Externally publishedYes

Keywords

  • Cephalosporins
  • Orthopaedic surgery
  • Prophylaxis
  • Teicoplanin
  • Vancomycin
  • Vascular surgery

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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