Peptide YY (PYY) immunoreactivity is co-stored with glucagon-related immunoreactants in endocrine cells of the gut and pancreas

A. Ali-Rachedi, I. M. Varndell, T. E. Adrian, D. A. Gapp, S. Van Noorden, S. R. Bloom, J. M. Polak

Research output: Contribution to journalArticlepeer-review

186 Citations (Scopus)

Abstract

In this study we report the localisation of PYY immunoreactivity in intestinal mucosa endocrine (EG) cells containing glucagon-related peptides and also in foetal pancreatic A cells of rat and man. Radioimmunoassay of human foetal pancreatic extracts revealed the presence of PYY immunoreactivity, the concentration of which declined with age (from 65.42 pmol/g at week 20 to 17.0 pmol at week 40; correlation coefficient=-0.893), in contrast to the amount of glucagon which remained statistically constant throughout the same foctal period. The identity of this PYY immunoreactive material with the original 36 amino acid porcine peptide has been shown by high pressure liquid chromatography (HPLC).

Original languageEnglish
Pages (from-to)487-491
Number of pages5
JournalHistochemistry
Volume80
Issue number5
DOIs
Publication statusPublished - Sep 1984
Externally publishedYes

ASJC Scopus subject areas

  • Anatomy
  • Agricultural and Biological Sciences(all)

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