On-chip electroporation: Characterization, modeling and experimental results

Ebrahim Ghafar-Zadeh, Bahareh Gholamzadeh, Falah Awwad, Mohamad Sawan

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

In this paper, we describe an on-chip electroporation (EP) method for high precision nano-injection of bio-molecules into single cells. EP is an electrical stimulation method to create nano-pores on the cell plasma membrane. Herein, we first put forward the computational models of the cultured cells microelectrodes. We thereafter discuss practical considerations by demonstrating the preliminary experimental results. The mouse fibroblast cells are cultured above electrodes while experiencing a low frequency (10 Hz) electrical field (EF) in the presence of propidium iodide (PI).

Original languageEnglish
Title of host publication2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2012
Pages2583-2586
Number of pages4
DOIs
Publication statusPublished - Dec 14 2012
Event34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012 - San Diego, CA, United States
Duration: Aug 28 2012Sep 1 2012

Publication series

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)1557-170X

Other

Other34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2012
Country/TerritoryUnited States
CitySan Diego, CA
Period8/28/129/1/12

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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