Numerical revelation of the kinetic significance of individual steps in the reaction mechanism of methyl linoleate peroxidation inhibited by α-tocopherol

Levon Tavadyan, Avet Khachoyan, Gagik Martoyan, Afaf Kamal-Eldin

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

A kinetic model was constructed to describe the reactions involved in the oxidation of methyl linoleate (ML) inhibited by α-tocopherol (TH). The initial model of the reaction mechanism included 53 individual steps, which were numerically analyzed by the value method based on Hamiltonian systematization of kinetic equations. Good accord was obtained with experimental data at 40 and 50 °C. The dominant steps responsible for the antioxidant and pro-oxidant properties of TH in the process of ML peroxidation were revealed. Tocopherol-mediated peroxidation (TMP) and generation of alkoxyl radicals as a result of the reduction of hydroperoxides by TH or the decomposition tocopherol alkyl peroxides are the dominant reactions responsible for the pro-oxidant activities of α-tocopherol. The extreme behavior of reaction induction period in relation to TH initial concentration is related to the increase in the ratios of [tocopheroxyl radical]/[peroxyl radical] and the TMP rate/rate of termination by combination of tocopheroxyl and peroxyl radicals.

Original languageEnglish
Pages (from-to)30-45
Number of pages16
JournalChemistry and Physics of Lipids
Volume147
Issue number1
DOIs
Publication statusPublished - May 2007
Externally publishedYes

Keywords

  • Antioxidants
  • Kinetic model
  • Lipid peroxidation
  • Methyl linoleate
  • Numerical analysis
  • α-Tocopherol

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Cell Biology

Fingerprint

Dive into the research topics of 'Numerical revelation of the kinetic significance of individual steps in the reaction mechanism of methyl linoleate peroxidation inhibited by α-tocopherol'. Together they form a unique fingerprint.

Cite this