Novel marine-derived anti-cancer agents

Thomas E. Adrian

Research output: Contribution to journalReview articlepeer-review

44 Citations (Scopus)

Abstract

There is an immense diversity of marine plants and animals from which an estimated 14,000 pharmacologically active compounds have been isolated. However, in terms of clinically useful anti-cancer agents, the oceans remain as a largely untapped resource. Indeed, there are currently only two compounds used in the clinic that are derived from marine sources. These are cytarabine, which is a deoxycitidine analogue and aplidine, which has both growth inhibitory and anti-angiogenic effects. This situation is likely to change rather dramatically in the near future, as attention has focused on the vast diversity of available agents from marine organisms. The increased pace of activity in this area has resulted in a several clinical trials of promising compounds with the probability that these will be followed by other drugs currently under preclinical development.

Original languageEnglish
Pages (from-to)3417-3426
Number of pages10
JournalCurrent Pharmaceutical Design
Volume13
Issue number33
DOIs
Publication statusPublished - Nov 2007
Externally publishedYes

Keywords

  • Aplidine
  • Ascididemin
  • Cephalostatins
  • Dideoxypetrosynol A
  • Protein kinase C

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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